2 Thealby Gardens
United Kingdom
Danum International Limited
Tel: +44(0)1302 371500

New, efficient and safe diagnostic breast imaging



Dynamic Optical Breast Imaging (DOBI) is a low cost, non-invasive optical mammographic technique to obtain physiological information on angiogenesis in breast tissue. Angiogenesis reflects the potential aggressiveness of malignant lesions.

Slight pressure is applied to the breast (10mmHg) and near-infrared light (640nm) from an array of light emitting diodes (LED) is used to illuminate the breast.  A camera system records several images per second of the light transmitted through the breast tissue for approximately 45 seconds.  Light absorption by the tissue varies according to the haemoglobin/deoxyhaemoglobin ratio.  A software application generates colour breast images that map the relative concentrations of deoxyhaemoglobin in the breast tissue and thus permit evaluation of vascularity.

ComfortScan is a DOBI device that can be used in mammography screening procedures, symptomatic breast imaging and follow-up imaging (symptomatic). Its use is particularly recommended for examinations of younger patients.

New, efficient and safe diagnostic breast imaging.


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  • Comfortable and quick
  • Non-radiographic therefore non-invasive


  • Real time, high resolution data acquisition
  • Using monochromatic red light and a proprietary image processing algorithm

Connectivity or Versatility

  • The imaging platform can be enhanced and used in conjunction with other diagnostic systems, including conventional and digital mammography (FFDM), ultrasound and MRI

Unparalleled Advantages

Dynamic Optical Image

  • Extremely sensitive to light absorption variations in pressure stimulated blood vessels

Angiogenesis Highlighting

  • Visualisation of the abnormal vascular bed. Results in a reduction in diagnostic ambiguity

Gentle Compression

  • Sufficient pressure to detect the angiogenesis (only up to 10mmHg)

High Intensity LED's

  • A sophisticated optical system optimises the light intensity to the different breast densities creating diagnostic images without ionizing radiation

Rapid Scanning Time

  • Images acquired in less than 1 minute


  • Examinations can be made from the age of 18 to provide very early breast tumour diagnosis

Tumour Angiogenesis Nutrient Supply for Tumour

Highly advanced vascular investigation providing a timely diagnosis to enable early treatment.


  • In 1994 the Angiogenesis Foundation identified angiogenesis as the "common denominator" in many important diseases, including breast tumour


  • Proves that a breast tumour becomes clinically relevant once it develops a blood supply vascular network

Early vascular detection

  • Subtle vascular changes are often associated with breast cancer in its earliest stages

Advanced Performance Technology

  • Detects the vascular changes and defines a unique vascular profile indicating the early development of a tumour angiogenesis
Pre-Angiogenesis Tumour Early Stage Angiogenesis Advanced Angiogenesis

Pre-Angiogenesis Tumour

Early Stage Angiogenesis

Advanced Angiogenesis

Needs a blood supply to grow.
More nutrient vessels often result
in more aggressive growth.

Capillary vessel growth often promotes rapid tumour

A dense network of blood vessels fuels the tumour growth

ComfortScan for Improved Diagnostic Analysis

Rapid and Efficient System for periodic patient diagnosis and monitoring

ComfortScanImproved diagnosis of patients with breast cancer symptoms.
Broader patient reach through the continuous monitoring of familial breast cancer in young women.
Periodic monitoring of the pathological changes that X-ray mammography cannot identify.
Ensures regular compliance for post-mammography examination of high risk mastopathy patients.

ComfortView Diagnostic Software

ComfortViewRapid and dynamic analysis of the images captured by ComfortScan.
Colour images of the breast with chromatic mapping to highlight zones of increased vascularisation.
Real-time graphic measurement of the haemodynamic response to a pressure stimulus of the target zone.
Digital image archiving for post-diagnostic review.


Clinical Case Studies


66-year-old woman with 10mm suspected lesion, BI-RADS 3.

Malignant Lesion

Mammography reported “benign and inconclusive” by 2 operators: UNCERTAIN.
ComfortScan revealed the presence of a significant angiogenesis: MALIGNANT.
Biopsy revealed an invasive ductal Stage III carcinoma: CONFIRMED MALIGNANT.


48-year-old woman with 10mm suspected lesion, BI-RADS 3.

Benign Lesion

Mammography inconclusive: UNCERTAIN.
ComfortScan does not reveal any angiogenesis symptoms: BENIGN.
Biopsy is benign: CONFIRMED BENIGN.

ComfortScan Technical Specifications

Patient position standing
Breast support height 99 cm above floor, min
  140 cm above floor, max
Breast support tray 25cm wide; 23cm depth
Breast compression 10mm Hg pressure, typical
Length   145 cm
Width 61 cm
Height 165 cm min to 206 cm max
Weight 295 kg
Source monochromatic red LED
Wavelength 627 nm, typical
Number of LED's 127
Imaging system  
CCD Resolution 768 x 512,9 micron pixel
Dynamic Range 4096 (12 bit)
ADC Gray scale 4096 levels
CCD Operating Temp 0°C
System noise < 70 electrons (RMS)
Lens   8 mm, focal length 3
Power Supply  
Input voltage and current 2A - 240V  
PC system
CPU Intel Pentium IV 2GHz
Memory 512MB RAM
Hard Disk 40 GB
CD-R 52x Read/Write
Video Memory 64 MB
Operating system MS windows XP
Archive CD-R 640MB
Monitor Technology Flat panel, LCD display
Monitor Size 15” (38cm)
Safety Norms
Electromechanical Safety UL60601-1
Electromagnetic Compatibility EN60601-1-2
Electro medical Safety EN60601-1
System Safety EN60601-4
Risk Analysis    EN1441
Symbology EN980

For further information regarding ComfortScan, please call 01302 371500 or email information@danum.com.

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